TNF and periodontal disorder: The translocation of periodontal pathogens to the fetoplacental unit or the effect of inflammatory mediators, like interleukin-1 (IL-1), IL-6, IL-8, tumor necrosis factor-α (TNF-α), or prostaglandin E2 (PGE2), explains the possible link of periodontal diseases and various adverse pregnancy outcomes [7–9].