Several risk markers related to the immune response that have key roles in atherosclerosis were identified, including the top aging marker MMP8, disease markers KIR3DL1 and MAGEA6, network markers based on degree (RBM10, PJA2, and CMTM6; Table 4), and network markers based on betweenness (IRAK1 and VAMP8). The gene discussed is PJA2; the disease is atherosclerosis.