Using the rodent model, McCarthy et al. (2020) reported that BRD2 gene haploinsufficiency led to GABA neuron deficits in the striatum and primary motor neocortex as early as P15, and seizure susceptibility increased from the P30 but not in younger animals (corresponds to the human JME onset pattern). The gene discussed is BRD2; the disease is juvenile myoclonic epilepsy.