Moreover, the GRIN2A-related epilepsy-aphasia spectrum is broad and ranges from the mild end, such as CECT, to the severe end, such as Landau-Kleffner Syndrome (LKS) and Continuous Spike and Wave During Sleep (CSWS) in DEE (Carvill et al., 2013; McTague et al., 2016). Here, GRIN2A is linked to developmental and/or epileptic encephalopathy with spike-wave activation in sleep.