Using the previously described Pten-RNAi/RASV12 overexpression-induced GBM model (Cheng et al., 2016), Minata et al. (2019) demonstrated that Tep1 (CD109 in mammals) loss in glioma cells reduces Yki (the Drosophila YAP/TAZ ortholog) and attenuates gliomagenesis. Here, YAP1 is linked to central nervous system cancer.