AKT1 and central nervous system cancer: Similarly, overexpression of KRASG12V in a putative neural stem and/or progenitor cells induced brain tumorigenesis (Ju et al., 2015) and overexpression of dominant-active human Akt1 (DAAkt1) or Rac1G12V (DARac1) (Ptf1a promoter)-induced gliomas of various histological grades, frequently infiltrated (Jung et al., 2013).