Many of the key signalings perturbed in GBM, such as EGFR signaling and the phosphatidyl-inositol-3-kinase (PI3K) pathway (Brennan et al., 2013), are conserved in Drosophila. Moreover, single functional orthologs exist for most of these genes, such as EGFR (dEGFR), PIK3CA (dp110), PTEN (dPTEN), RAS (dRas), RAF (dRaf), and AKT (dAkt). This evidence concerns the gene PIK3CA and glioblastoma.