In a high‐fat diet (HFD)‐induced NAFLD model, HMGB1 expression and extracellular release are potentiated by a saturated fatty acid (palmitic acid) in vitro, whereas the neutralization of endogenous HMGB1 dampens HFD‐induced inflammatory responses and impairment of liver functions in vivo.46 Here, HMGB1 is linked to metabolic dysfunction-associated steatotic liver disease.