In addition to genes with ion binding and membrane transport functions, the 20‐gene tolerance signature also includes the gene NGB, which is upregulated in infection‐tolerant embryos and is involved in increasing oxygen availability, which provides protection under hypoxic and ischemic conditions.[30] The gene HNF4A, which was identified as a major gene network hub in tolerance networks, is also the most upregulated component of the gene signature. The gene discussed is HNF4A; the disease is infection.