Our study showed that Hs-TnI ≥ 0.131 ng/ml, PCT ≥ 40 ng/ml, Lac ≥ 4.2 mmol/L, and NT-proBNP ≥ 3270 pg/ml are independent risk factors for left ventricular systolic dysfunction in patients with sepsis and the predictive model is acceptable. The gene discussed is NPPB; the disease is Sepsis.