Through neuroinflammation signaling pathway, osteoarthritis pathway, glucocorticoid receptor signaling, ILK signaling, IL-17 signaling and HIF1α signaling (Fig. 8C) etc. GABA might participate in inflammatory response, organismal injury and abnormalities, cancer, infectious diseases, skeletal and muscular disorders, neurological disease (Fig. 8E) etc. This evidence concerns the gene IL17A and osteoarthritis.