The characteristics of the enrolled subjects, including age, duration of RA, body mass index (BMI), white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), platelet (PLT), albumin (ALB), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF)-IgG, RF-IgA, RF-IgM, smoked, hypertension, diabetes and coronary heart disease were shown in Table 1. The gene discussed is CD40LG; the disease is diabetes mellitus.