Through neuroinflammation signaling pathway, osteoarthritis pathway, glucocorticoid receptor signaling, ILK signaling, IL-17 signaling and HIF1α signaling (Fig. 8C) etc. GABA might participate in inflammatory response, organismal injury and abnormalities, cancer, infectious diseases, skeletal and muscular disorders, neurological disease (Fig. 8E) etc. The gene discussed is HIF1A; the disease is muscle tissue disorder.