By integrating and analyzing samples from multiple previous studies, we present a wider view of the genetic landscapes of acral and mucosal melanomas (Fig. 8), provide additional support for the pathogenetic relevance of previously nominated genes, and implicate additional likely driver genes such as PTPRJ, FER, and SKP2 altered in a subset of acral and mucosal melanomas. The gene discussed is SKP2; the disease is melanoma.