Differentially expressed genes (DEGs) analysis showed, in line with the Grubman et al. 2019 data, that the m1 PIEZO1 cells were enriched with (1) AD GWAS genes APOC1 and APOE; and (2) mitochondrial genes LINGO1, MT-ND4, MT-ND2, SNX6, MT-ATP6, MT-CYB, MT-CO2, and MT-CO3; but had (3) low levels of AD GWAS gene FRMD4A (Additional file 1: Table S3). The gene discussed is MT-ND4; the disease is Alzheimer disease.