PIEZO1 and Alzheimer disease: As we demonstrate the beneficial effects of PIEZO1 activation both in human microglia in vitro and in an animal model of AD in vivo, this calcium-permeable mechanoreceptor could represent a novel translational target for LOAD patients covering the majority of AD cases associated with impairment in the clearance of Aβ [3, 4] We show that functional PIEZO1 channels are expressed in human and mouse microglia and that Aβ1-42 compromises PIEZO1-mediated Ca2+ signaling in human iMGLs.