Our reanalysis of single-cell transcriptomic datasets of AD patients [40] and DAM microglia in 5xFAD mice [41, 42] showed apparently contradicting PIEZO1 upregulation in a human AD-associated microglial subpopulation and, on the other hand, downregulation of Piezo1 in mouse DAM. Here, PIEZO1 is linked to Alzheimer disease.