In addition, accumulating evidence demonstrated that DEPDC1B plays a key regulatory role in the progression of multiple cancers, including non-small-cell lung [12], hepatocellular [26], and bladder cancers [17], etc. For examples, silenced DEPDC1B could inhibited cell proliferation and induced cell apoptosis in malignant melanoma which is in agreement with our findings [19]. This evidence concerns the gene DEPDC1B and melanoma.