Not surprisingly, knockdown of GABRD inhibited the malignant phenotypes of ESCC cells, which was manifested as inhibition of cell viability and proliferation (p < 0.01, Fig. 4E, F), enhanced apoptosis rate (p < 0.01, Fig. 4G), and impaired migration (p < 0.01, Fig. 4H, I). The gene discussed is GABRD; the disease is esophageal squamous cell carcinoma.