The ability of β-catenin in upregulating stemness markers including CD44 and epidermal growth factor receptor (EGFR) in OSCC and HNSCC have also recently been documented [48–50], prompting us to investigate whether EGFR and CD44 were also regulated by KRT17-mediated signaling cascade of integrin/Src/ERK/β-catenin. The gene discussed is KRT17; the disease is head and neck squamous cell carcinoma.