As Wnt/GSK3β/β-catenin axis is often reported to be activated by Src and ERK and results in nuclear translocation of β-catenin and tumor progression [42, 44, 45], we then examined subcellular localization of β-catenin and found that both cytoplasmic and nuclear active (unphosphorylated) β-catenin was markedly reduced upon KRT17 depletion (Fig. 3E). The gene discussed is SRC; the disease is neoplasm.