Comorbidities as well as acute stressors (i.e., ischemia, increased myocardial wall tension, hemodynamic overload) lead to the activation of the inflammatory response in the heart with activation of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome, subsequent maturation and release of proinflammatory cytokines such as Interleukin-1beta (IL-1β) and IL-18 [13]. Here, IL1B is linked to ischemia.