In the study of choriocarcinoma, β-Catenin, as a critical mediator of the Wnt signaling pathway, promotes the proliferation of human choriocarcinoma cells via the LIN28B/Let-7a/IMP1 pathway which mediates inhibition of let-7a, promotes IMP1 expression and thereby promotes proliferation of JAR cells. Here, IGF2BP1 is linked to choriocarcinoma.