In our study, we focused on CCDN1 and CDK4, as the cyclinD1-CDK4 dimer normally inhibits the pRb protein allowing the E2F transcription factor to transcribe the genes necessary for entry into the S phase, while in an HPV-mediated infection E7 binds to pRb thus modifying the normal control of the cell cycle [58, 59]. This evidence concerns the gene RB1 and infection.