When we compared DNAm patterns in AML patients with other DNMT3A mutations to AML patients without DNMT3A mutations, the general hypomethylation was much less pronounced and only 896 CpGs revealed 20% lower DNAm with DNMT3A mutation, while 181 CpGs had at least 20% higher DNAm levels (Fig. 5d). Here, DNMT3A is linked to acute myeloid leukemia.