Conversely, tetraiodothyroacetic acid (tetrac), the deaminated analog of T4, and its nano-derivative (NDAT) suppress the ERK1/2 and STAT3 activation by blocking cell surface integrin αvβ3, with effective anti-proliferation against non-small-cell lung cancer (NSCLC) cells [12]. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.