These results indicated rE4 and Aβ42 could induce more cPLA2 translocation than rE3 in the vesicle enriched cytosolic fraction of synaptosomes, suggesting that greater cPLA2 activation in the human cortex of AD E3/E4 compared to AD E3/E3 might arise from the concurrent effects of ApoE4 and greater Aβ42 accumulation. Here, PLA2G4A is linked to Alzheimer disease.