In a second brain cohort from the USC ADRC neuropathology core (Supplementary Table 1), nonsignificant differences were observed in phosphorylated cPLA2/total cPLA2 in the hippocampus of the APOE4/E4 AD group compared to the APOE3/E3 NCI group (Fig. S5A), despite a significantly greater ratio of phosphorylated p38/ total p38 (Fig. S5B). Here, PLA2G4A is linked to Alzheimer disease.