FKBP5 and Anxiety: These results indicated that Fkbp5 deficiency diminished anxiety-like behavior in the GC-induced stress model, which differs from the inflammation-induced anxiogenic effect observed in Fkbp5-KO mice (Fig. 1), suggesting the anxiety following inflammation (particularly innate immunity) is distinctly regulated by a set of neuro-mechanisms from that following the GC-induced stress.