Proteomic analysis of tyrosine phosphorylation of synaptic glutamate receptors, including α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and NMDA receptors, found persistently upregulated NR2A-Y1246 and NR2B-Y1472 after brain ischemia [66]. This evidence concerns the gene GRIN2B and brain ischemia.