TP53 and cholangiocarcinoma: For a more intuitive comparison between pancreatobiliary-type AAC and the other two cancer types, the paired bar charts of the mutation rate for pancreatobiliary-type AAC vs. PAC and pancreatobiliary-type AAC vs. cholangiocarcinoma are shown in Fig. 6D, E. As we can see, both pancreatobiliary-type AAC and PAC had high frequency of mutations in TP53 and KRAS (more than 60%).