Furthermore, the expression of CD81 in B cells from SLE patients was down-regulated, and that could be correlated with abnormal activation of B cells (especially antibody secreting cells) and disease activity (especially at the active stage) (Henriques et al. 2016; Abu-Zahab et al. 2017; Dang et al. 2022). The gene discussed is CD81; the disease is systemic lupus erythematosus.