Several pathways linked to methylation and acetylation were enriched in YM ICM and TE in relation to numerous upregulated genes in YM ICM compared to OM (i.e., Histone Deacetylase 1 and 2, HDAC1 and HDAC2; Helicase, Lymphoid Specific, HELLS; DNA Methyltransferase 3 Alpha, DNMT3A; Lysine Acetyltransferase 6B, KAT6B; Lysine Demethylase 4A, KDM4A; Lysine Methyltransferase 2A, KMT2A; Nuclear Receptor Binding SET Domain Protein 3, NSD3; SET Domain Containing 5, SETD5; Tet Methylcytosine Dioxygenase 1, TET1). This evidence concerns the gene SETD5 and ocular melanoma.