Several signaling pathways required for development were altered and numerous genes related to focal adhesions and signaling pathways were down-regulated in OM ICM compared to YM (ARHGAP9 and ARHGAP35; B-Raf Proto-Oncogene, Serine/Threonine Kinase, BRAF; Filamin C, FLNC; FYN Proto-Oncogene, Src Family Tyrosine Kinase, FYN; PAK3; Protein Phosphatase 1 Regulatory Subunit 12A, PPP1R12A; Talin 2, TLN2; X-Linked Inhibitor Of Apoptosis, XIAP). The gene discussed is MARK2; the disease is ocular melanoma.