CD274 and neoplasm: Notably, Wan and colleagues [66] have recently generated short-term co-cultures containing tumour organoids and the full complement of intratumoral immune cells from 12 solid tumors of HGSOC patients to test a unique bispecific anti-PD-1/PD-L1 antibody compared with monospecific anti-PD-1 or anti-PDL1 controls.