Focal LOH was also observed on 9q around TSC1, 13q around BRCA2 and RB1, and 19p around STK11. By contrast, CN17-attributed sarcomas displayed strong peaks of recurrent LOH around known sarcoma tumour suppressor genes46 (CDKN2A, RB1 and TP53; Extended Data Fig. 7l). This evidence concerns the gene TSC1 and sarcoma.