In stratified analyses, relative IL-6 mRNA expression was significantly up-regulated in the synovium of knee OA patients with high-grade synovitis, as compared to those without synovitis (P < 0.05) (Fig. 1j), consistent with NF-κB mRNA expression analysis (P < 0.05) (Fig. 1k). The gene discussed is NFKB1; the disease is synovitis.