CNR2 and irritable bowel syndrome: In similar studies on cannabinoid receptors , Rousseaux et al. in 2007 reported that among a diversity of bacteria used in the study (including: L. acidophilus NCFM, L. salivarius Ls-33, L. paracasei Lpc-37, B. lactis Bi-07 and B. lactis Bl-04, and two E. coli strains), only active and heat-inactivated Lactobacillus acidophilus NCFM , known as a probiotic, could increase the CB2 mRNA level in HT-29 epithelial cells that made it a considerable candidate for the treament of irritable bowel syndrome and abdominal pains60.