While we included ATRX in the epigenetic pathway gene list owing to its product’s fundamental role, along with DAXX, as a histone variant H3.3 chaperone, ATRX also participates in other pathways including telomerase-independent alternative lengthening of telomeres (ALT), which has been observed in a number of soft tissue sarcomas including UPS and liposarcoma51. The gene discussed is DAXX; the disease is soft tissue sarcoma.