Many of the sarcomas with infrequent alterations (<10%) in the cell cycle and TP53 pathways were driven by translocations (e.g. MRLS, DSRCT, SYNS) or alteration in genes encoding components of the SWI/SNF remodeling complex (epithelioid sarcoma [EPIS]) (Fig. 4A), highlighting a distinct mechanism of pathogenesis. This evidence concerns the gene SMARCA1 and epithelioid sarcoma.