In particular, CNV was more frequent in CCND3, AURKB, CCNE1, GID4, and MYC in P-AYA, while MDM2, CDKN2A/B, and FRS2 were more frequently altered in adult osteosarcoma (p < 0.001) (Supplementary Fig. S5). Here, MDM2 is linked to osteosarcoma.