The frequencies of alterations differed between complex sarcomas and translocation-associated sarcomas within TP53 (44.9% vs. 11.3%), RB1 (21.5% vs 2.8%), CDKN2A (19.0% vs. 9.0%), MDM2 (13.5% vs. 1.6%), CDK4 (12.8% vs. 3.3%), MDM4 (0.6% vs. 0.2%), CCND1 (1.2% vs. 0.3%), CCND2 (1.7% vs. 0.3%), CCND3 (2.3% vs. 0.2%), and CCNE1 (3.2% vs. 0.5%). The gene discussed is MDM4; the disease is sarcoma.