Oncogenic drivers common in melanoma or epithelial cancers, such as BRAF V600E (0.5%) KRAS G12X (0.9%), and exon 19 deletions (0.01%) and L858R (0.01%) mutations in EGFR, are rare in mesenchymal sarcomas and raise the possibility of identifying epithelial malignancies with sarcomatoid differentiation. Here, KRAS is linked to melanoma.