While the gene set in this panel is extensive, it does not cover many genes that may be important in sarcomas such as MYOD1, VEGFA, TERT, MTAP, and POLE/D and many emerging pathways such as Hippo (YAP1, TAZ); underscoring the importance of gene panels to be continuously refined based on emerging knowledge. The gene discussed is YAP1; the disease is sarcoma.