Taurine upregulated gene1 (TUG1) regulates the expression of LIMK2b (a splice variation of LIM-kinase 2) by means of binding to the enhancer of EZH2, and mediate chemoresistance in SCLC.112 Furthermore, new findings reveal that EZH2 promote DDB2 stabilization and NER in a non-catalytic and PRC2-independent way and reverse cisplatin resistance in SCLC, suggesting a rationale for overcoming cisplatin resistance in SCLC by targeting EZH2 beyond its catalytic activity.113. This evidence concerns the gene TUG1 and small cell lung carcinoma.