Notch signaling was demonstrated to drive plasticity from neuroendocrine (NE) to nonneuroendocrine (nonNE) phenotypes.81 It was investigated that inactivating Notch mutation could improve nonNE tumor cells or precursors to neuroendocrine differentiation.82 Notch-ASCL1 signaling contributes to drive and maintain the phenotype of small cancer cells. The gene discussed is ASCL1; the disease is neoplasm.