Further, to determine if LOXHD1 mediates HIF1α stabilization, we treated the control and eKD cells with an iron chelator desferrioxamine (DFO), which disrupts the function of iron-dependent PHDs in maintaining HIF1α stabilization (Epstein et al., 2001; Semenza, 2012) and found no differential stability of HIF1α in eKD cells compared with controls (Figure S6H). The gene discussed is LOXHD1; the disease is episodic kinesigenic dyskinesia.