Remarkably, the invasive potential of LOXHD1-proficient EwS cells was amplified under hypoxic conditions confirming earlier reports that hypoxia promotes sarcoma invasion and metastasis (Aryee et al., 2010; Brizel et al., 1996; Eisinger-Mathason et al., 2013; El-Naggar et al., 2015) (Figures 6A, S6A, and S6B). The gene discussed is LOXHD1; the disease is sarcoma.