The NR4A family of nuclear receptors is gaining attention for therapeutic potential especially in neurodegeneration[24] and cancer.[9] While there has been considerable progress in ligand discovery for Nur77 (NR4A1) and Nurr1 (NR4A2), NOR‐1 (NR4A3) modulators are still lacking but needed as chemical tools to enable further research on the receptor′s therapeutic potential. The gene discussed is NR4A1; the disease is cancer.