TLR2 and systemic lupus erythematosus: Previously, Azzouz et al. provided evidence that Ruminococcus gnavus (family Lachnospiraceae) is a pathobiont overrepresented in SLE gut dysbiosis and elicits specific autoantibody responses correlating with anti-dsDNA levels, SLE disease activity, and lupus nephritis in particular.32R. gnavus specific lipoglycans were proposed as novel immunodominant antigens as well as innate stimuli in SLE through the binding of TLR2.