CALR and Autoimmunity: For example, a murine TNFR2 knockout model of demyelinating autoimmune disease demonstrated a contraction of bacteria that tonically suppress inflammation, and an expansion of Clostridium perfringens, a taxon with a bacterial protein that shares molecular mimicry with the myelin of nerve cells.6 Thus, a focus on associations of taxa and immunological tolerance, within a cohort of anti-Ro positive mothers of neonatal lupus children, may enlighten our understanding of preclinical autoimmunity.