TNF and chronic obstructive pulmonary disease: In addition, genes in the top ten degree were selected (Fig 3C), the results showed that AKT Serine/Threonine Kinase 1 (AKT1), Interleukin-6 (IL6), Tumor necrosis factor (TNF), Tumor Protein P53 (TP53) and Matrix Metalloproteinase 9 (MMP9) were the most vital targets of PPI, which may be the main targets of AJH in COPD treatment.