TNFα antagonists, for example, infliximab, adalimumab, certolizumab, and golimumab, are widely used in the treatment of a number of autoimmune and inflammatory conditions, including juvenile idiopathic arthritis, psoriasis and psoriatic arthritis, ulcerative colitis, rheumatoid arthritis, axial spondyloarthritis, ankylosing spondylitis, Crohn's disease, and ulcerative colitis. The gene discussed is TNF; the disease is ulcerative colitis.