The role of the environment cannot be ignored, although the genetic variants in the adiponectin and leptin genes have effects on energy consumption and weight gain.24,25 However, the understanding of the genetic mechanisms involved in the genesis of obesity is necessary for the development of interventions even in childhood and adolescence that can prevent future health problems, which in some cases are irreversible, but which can be mitigated by a team of interdisciplinary health professionals. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.