This dysfunction is closely related to DM, hypertension (HT), and atherosclerotic heart diseases.25 It has been reported that adropin reduces endothelial permeability and prevents the passage of macrophages in response to inflammatory stimuli, ultimately reducing inflammation.19 In our study, serum adropin levels, which were initially low in the DM patients, may have decreased further with the addition of COVID-19 and increased endothelial damage. The gene discussed is ENHO; the disease is COVID-19.