It is reviewed that ASXL1, EZH2, IDH1, IDH2, TP53, or SRSF2 mutations are associated with a short survey and leukemic transformation and homozygote JAK2 V617F mutation causes more clinical symptoms and indicates poor prognosis in PM cases.21 Four of the PV patients had mutations; 1 had JAK2 V617F ve JAK2 C618R, 1 had DNMT3, 1 had MPL, and the other had FLT3 mutations. This evidence concerns the gene EZH2 and acquired polycythemia vera.