TP53 and acute myeloid leukemia: The main somatic mutations in MDS are TET2, ASXL1, SRSF2, RUNX1, TP53, EZH2, ZRSR2, SF3B1, and ETV6 mutations.8TP53 mutation is associated with short survival, high risk of AML transformation, increased blast percentage, and complex karyotype.9SF3B1, SRSF2, and U2AF1, splicesome group gene mutations, are seen in more than 50% of MDS patients.