The main somatic mutations in MDS are TET2, ASXL1, SRSF2, RUNX1, TP53, EZH2, ZRSR2, SF3B1, and ETV6 mutations.8TP53 mutation is associated with short survival, high risk of AML transformation, increased blast percentage, and complex karyotype.9SF3B1, SRSF2, and U2AF1, splicesome group gene mutations, are seen in more than 50% of MDS patients. The gene discussed is U2AF1; the disease is acute myeloid leukemia.