In AML; FLT3 (4 times), DNMT3A (3), NPM1 (3), IDH2 (2), NRAS (2), TP53 (2), ASLX1 (2), IDH1 (1), EZH2 (1), TET2 (1), KRAS (1), and SF3B1 (1) mutations were detected. The gene discussed is SF3B1; the disease is acute myeloid leukemia.