In addition to HSPA-2 being excessively expressed in different types of cancer, there are a few studies showing that it has an effect on tumor progression.11-17 It is indicated that tumor cells gain resistance against apoptosis related to hypoxia with an increase of HSPA-2, and that is how they stay alive.22 It is also known that HSPA-2 migrates to the nucleus and nucleoli under stress conditions while it is localized in the cytoplasm under normal conditions. This evidence concerns the gene HSPA2 and neoplasm.