INS and type 1 diabetes mellitus: Because more individuals with T1D are overweight and obese than those without diabetes, indicating the presence of additional contributing mechanisms.21,22 Delivery of subcutaneous insulin in a non-physiological manner along with abnormal eating behavior in fear of hypoglycemia could be additional factors in the development of DD.23,24 Therefore, the development of IR in T1D subjects is secondary to a combination of unhealthy lifestyle choices as well as added diabetes-specific mechanisms.