STAT3 and neoplasm: Other studies have shown that Stt and Napabucasin (a small molecule that targets STAT-3) decrease cell renewal potential and the number of colonies, thus preventing metastasis into bone tissue of PCa in a mouse model (67) also, Terphenylin suppress the tumor growth and metastasis in mouse model of gastric cancer (68) In addition, STAT-3 inhibition via galiellalactone decreases formation of metastatic, clonogenic and spherical stem PCa and gastric cancer cells (69,70).