In particular, in PCa pSTAT-3 and IL-6R are present in 95% of metastatic niches of patients who die of castration-resistant PCa (CRPC); this suggests that in PCa, the activation of STAT-3 mediated by IL-6, IL-10 and EGF serves an important role for tumor progression and development of metastasis (10). This evidence concerns the gene EGF and neoplasm.