STAT-3 has key implications in cancer, cytokine storm, autoimmune disease and infection, included SARS-CoV2 (2), the development of therapies such as Stt + Tcz could improve the actual treatments again this pathway The present study demonstrated that Stt + Tcz was more effective than Stt or Tcz alone at inhibiting the IL-6/IL-6R/STAT-3 axis. This evidence concerns the gene IL6 and autoimmune disease.