These include (a) an abundance of CD8A+ tissue-resident T cells and interferon-stimulated gene–high (ISGhi) tumor-associated macrophages in RCC; (b) tissue-resident macrophages contributing to remodeling of the microenvironment during ICI treatment in lung cancer; (c) distinct neoantigen-specific TILs with specific transcriptional states; and others (103, 105, 106, 108, 138, 141). The gene discussed is CD8A; the disease is lung cancer.