Among 32 TCGA data sets of diverse human cancers (cBioPortal), endometrial carcinomas and carcinosarcomas are the 2 cancer types with the highest incidence of FOXA2 mutation, affirming that FOXA2 plays a particularly important — and perhaps unique — role in endometrial carcinogenesis (25). The gene discussed is FOXA2; the disease is endometrial carcinoma.