FOXA2 and neoplasm: In contrast, in our studies, Foxa2 inhibited cell cycle progression via Myc, albeit modestly, confirming that it is a multitasking tumor suppressor with diverse biological roles, but with a much more potent effect as an EMT suppressor, as evidenced by upregulation of EMT factors and the striking pro-invasive/pro-metastatic phenotypes observed in the live animal and human/mouse cell line and organoid systems.