RNF43 and colorectal carcinoma: To further investigate the expression level difference of sequentially validated fusion transcripts between metastatic and primary CRC tissues, we analyzed the 21 ADAP1‐NOC4L positive samples [13(56%) mCRC and 8(47%) pCRC] and 25 RNF43‐SUPT4H1 positive samples [15(60%) mCRC and 10(40%) pCRC], and found that higher relative expression of both candidate fusion transcripts (p = 0.041, p = 0.037) in liver metastasis samples compared to primary CRC tissues (Figure 6A,B).