In addition, the potential target proteins of the essential oil in leaves of C. grandis ‘Tomentosa’ were enriched in TNF signaling pathway, toll-like receptor signaling pathway, amyotrophic lateral sclerosis, neurotrophin signaling pathway, human cytomegalovirus infection, apoptosis, which were involved in neurodegenerative diseases. The gene discussed is TNF; the disease is amyotrophic lateral sclerosis.