on this basis, they discovered JQ-1-based PROTAC 9 (Figure 4), a uniquely potent degrader of BRD4 that inhibited the viability of human AML MV4-11 cells at low picomolar concentrations (IC50=3 pM; BRD4 DC50=0.87 nM).45 This evidence concerns the gene BRD4 and acute myeloid leukemia.