IL6 and early-onset autosomal dominant Alzheimer disease: Of note, IL-6 has not been found elevated with Alzheimer’s disease pathophysiology in our sample, unlike the rest of the CSF biomarkers measured in this study.2 This together with the fact that IL-6 showed no effect on other components suggests that this marker may be measuring another independent glial reaction to what was previously found in the other two components, and in this case, more directly related to the presence of very early Aβ pathology.