The KEGG pathways enriched with upregulated genes between the CoCl2 and untreated control groups included the HIF‐1 signaling pathway, central carbon metabolism in cancer, legionellosis, and the pentose phosphate pathway, and those enriched with downregulated genes included cell cycle, the p53 signaling pathway, and systemic lupus erythematosus, among others (Figure 3C,D). This evidence concerns the gene HIF1A and legionellosis.