CXCL8 and chronic rhinosinusitis with nasal polyps: Our study also detected the mRNA expression of IL‐8 under hypoxic conditions, and we found that both submerged culture and CoCl2 treatment induced an increased expression of IL‐8 in CRSwNP‐derived epithelial cells (Figure S2), thus implicating the role of hypoxia‐induced upregulation of IL‐8 in mediating neutrophil inflammatory responses in CRSwNP.