In animal studies of bladder, renal cell, and CRCs, CXCL5 secreted by tumor cells binds its receptor CXCR2 and activates the downstream AKT/NF‐κB signaling pathway, thereby stimulating the proliferation and aggregation of endothelial cells.274, 275, 276. This evidence concerns the gene CXCR2 and neoplasm.