Immunohistochemical analysis of specimens from various tumors (including ovarian cancer,397 CRC,398 prostate cancer,399 melanoma,400 clear renal cell carcinoma,401 and nasopharyngeal carcinoma402) showed that CXCL13 and CXCR5 were markedly elevated in tumors, as compared with normal tissue, and contributed to the ability of tumor cells to proliferate, migrate, and invade, ultimately affecting tumor progression, metastasis, and OS. This evidence concerns the gene CXCR5 and neoplasm.