CD8A and chronic hepatitis B virus infection: revealed that in patients with chronic hepatitis B (CHB), CXCR5+CD8+ T cells were partially depleted but possessed greater antiviral capacity than the CXCR5− subpopulation; furthermore, the CXCL13 from CHB patients promoted the infiltration of intrahepatic CXCR5+CD8+ T cells, a subpopulation that produces anti‐HBV‐specific IFN‐γ and IL‐21 and improves treatment response in CHB patients.