Meanwhile, a Pearson correlation coefficient was used for estimating the association between SELL and other checkpoint molecules (CD274, CTLA4, HAVCR2, LAG3, PDCD1) and Teff (effector T-cell) gene signatures (CD8A, CXCL6, CXCL10, EOMES, GZMA, GZMB, IFNG and TBX21) which have been reported as biomarkers related with cancer immunotherapy (Socinski et al., 2018). This evidence concerns the gene CTLA4 and cancer.